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ACUTE-PHASE REACTIONS, INCLUDING CYTOKINES, IN PATIENTS BITTEN BY BOTHROPS AND CROTALUS SNAKES IN BRAZIL J. Venom. Anim. Toxins
BARRAVIERA,B.; LOMONTE,B.; TARKOWSKI,A.; HANSON,L. Å.; MEIRA,D.A..
Thirty-one patients bitten by venomous snakes in Botucatu area (State of São Paulo - Brazil), sixteen by Bothrops spp. and fifteen by Crotalus durissus terrificus, were studied. The group comprised twenty-nine males and two females, ranging from fourteen to sixty-three years of age (mean 33 ± 15). Leukocytosis with neutrophilia and lymphopenia, increase of mucoproteins and C-reactive protein, decrease of total serum protein and albumin, were observed on the first day after the accident. In addition, increased serum levels of the cytokines IL-6 and IL-8, but not of IL-1<FONT FACE="Symbol">b</FONT> and TNF-<FONT FACE="Symbol">a</FONT>, were observed. The alterations were generally more intense in patients bitten by Crotalus durissus...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Snake venom; Acute-phase reactions; Cytokines; C-reactive protein; Inflammation.
Ano: 1995 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301995000100003
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An evaluation by rat colon anastomosis of the efficacy of fibrin glue derived from snake venom J. Venom. Anim. Toxins
LEITE,C.V.S.; NARESSE,L.E.; ARANTES,H.L.; LOPES,A.F.; THOMAZINI-SANTOS,I.A.; GIANNINI,M.J.S; MERCADANTE,M.C.; BARRAVIERA,B.; KOBAYASI,S..
The objective of this study was to evaluate the efficacy of fibrin adhesive made up of snake venom and bubaline fibrinogen by rat colon anastomosis. Eighty rats were randomly assigned into 2 experimental groups: GI control (anastomosis with extramucous interrupted suture) and GII (repair suture + fibrin glue). The animals were studied at the following 4 times: T0 – preoperative, T1 – 7th day postoperative, T2 – 14th day postoperative, and T3 – 21 st day postoperative. The macroscopic characteristics of the intestinal segment open and closed anastomosis and the bursting strength of the anastomosed segments were observed at each of the above times. The results showed that the anastomosed segments coapted and there was no difference in the bursting strength...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Fibrin glue; Experimental healing; Bursting strength; Experimental anastomosis; Snake venom; Colon anastomosis.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302000000200004
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ANTITUMOR EFFECT OF SNAKE VENOMS J. Venom. Anim. Toxins
SILVA,R. J. DA; FECCHIO,D.; BARRAVIERA,B..
The search for biological antitumor agents has been pursued for over half a century. Snake venom has been shown to possess a wide spectrum of biological activities. The objectives of the present review are to evaluate the existing controversies on this subject published in a number of papers and to propose probable explanations for the phenomena observed. We reported our results obtained in a study, in which we evaluated the action of the venoms of Crotalus durissus terrificus and Bothrops jararaca on Ehrlich ascites tumor cells. We noticed an important antitumor effect, mainly with Bothrops jararaca venom, as well as an increase in the functional activity of macrophages. We also observed an increase in the number of mononuclear and polymorphonuclear cells...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cancer; Inflammation; Venom; Snakes; Crotalus durissus terrificus; Bothrops jararaca.
Ano: 1996 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301996000200002
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EFFECT OF Crotalus durissus terrificus (LAURENTI, 1768) VENOM ON THE EVOLUTION OF EHRLICH ASCITES TUMOR J. Venom. Anim. Toxins
SILVA,R. J. DA; FECCHIO,D.; BARRAVIERA,B..
The effect of Crotalus durissus terrificus (LAURENTI, 1768) venom on the evolution of Ehrlich ascites tumor cells was evaluated. Thus, 30-day-old male mice of the Swiss strain were inoculated intraperitoneally with 1x10<img SRC="http:/img/fbpe/jvat/v3n2/image1947.gif"> tumor cells. Then, 7 groups of animals were formed: 3 control groups (physiological, venom and tumor) and 4 experimental groups that received different doses of venom. The experimental groups received 5 intraperitoneal venom injections on the 1<img SRC="http:/img/fbpe/jvat/v3n2/image1948.gif"> , 4<img SRC="http:/img/fbpe/jvat/v3n2/image1949.gif"> , 7<img SRC="http:/img/fbpe/jvat/v3n2/image1949.gif"> , 10<img SRC="http:/img/fbpe/jvat/v3n2/image1949.gif"> and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Venom; Inflammation; Tumor growth; Crotalus durissus terrificus.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301997000200008
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Evaluation of the impact of printed matter, video, and multimedia on the learning/teaching process in tropical diseases J. Venom. Anim. Toxins
SARMENTO E SOUZA,M. F.; CATANEO,A.; BARRAVIERA,B..
This study evaluated the impact of printed matter, video, and multimedia on the learning/teaching process in Tropical Diseases. Eighty-four of 90 fourth-year medical students at Botucatu School of Medicine of UNESP were evaluated. The students received a kit containing a textbook, a video, and a CD-ROM on the Clinical Study of Tetanus to prepare a seminar on the subject. They were then asked to complete a questionnaire, which led to the following conclusions: 67.86% read the textbook, 91.66% watched the video, and 77.38% explored the CD-ROM. These results were obtained observing the total number of students using each different media. When asked which of these media contributed most, the CD-ROM came out on top. The authors stress that this learning...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Medical education; Tropical diseases; Multimedia; Video; Printed matter.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302001000200009
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EVALUATION OF THE INTRADERMAL SENSITIVITY TEST IN PATIENTS SUBMITTED TO HETEROLOGOUS SEROTHERAPY J. Venom. Anim. Toxins
AYRES,J. A.; BARRAVIERA,B..
This review deals with heterologous sera produced and used in Brazil. The authors studied 64 patients. Of these, 35 had been attacked by domestic and wild animals and received antirabies serum; 20 had been bitten by venomous animals (snakes and scorpions) and were treated with specific antivenoms; and 9 had traumas and received antitetanic serum All these patients were submitted to the intradermal sensitivity test before, and 30 days after reveiving heterologous serotherapy. The following results obtained by the authors agree with those in literature: - The intradermal test using undiluted heterologous serum produced a more acute reaction than that using heterologous serum diluted 1:10; - The larger the volume of serum, the larger was the wheal directly...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sensitivity test; Heterologous serotherapy.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301999000200003
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HUMAN ENVENOMATIONS DUE TO SNAKEBITES IN MARILIA, STATE OF SÃO PAULO, BRAZIL. A RETROSPECTIVE EPIDEMIOLOGICAL STUDY J. Venom. Anim. Toxins
SGARBI,L.P.S.; ILIAS,M.; MACHADO,T.; ALVAREZ,L.; BARRAVIERA,B..
Eighty-four patients bitten by venomous snakes were studied retrospectively at the School of Medicine of Marilia from January 1990 to August 1994. The majority of these patients were rural workers, 65 (77.38%) males and 19 (22.62%) females, aged eight to seventy-five. Forty-three (51.19%) patients were diagnosed as having been bitten by snakes of the genus Bothrops and 41 (48.81%) by Crotalus. Fifty-eight patients (69.04%) were bitten in the legs and 26 (30.96%) in the arms. January, March, April and November were the months of higher incidence of bothropic envenomations, while crotalic envenomations were not recorded only in August and September. This study showed that the prevalence of crotalic envenomations in Marilia was higher than that of any other...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Envenomations; Bothrops snakes; Crotalus snakes; Retrospective epidemiological study.
Ano: 1995 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301995000200004
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LOCAL EDEMA AND HEMORRHAGE CAUSED BY Crotalus durissus terrificus ENVENOMING EVALUATED BY MAGNETIC RESONANCE IMAGING (MRI) J. Venom. Anim. Toxins
FONSECA,M. G.; MATHIAS,M. R. C.; YAMASHITA,S.; MORCELI,J.; BARRAVIERA,B..
The objective of this study was to detect the presence of local edema and hemorrhage caused by Crotalus durissus terrificus envenoming using magnetic resonance imaging (MRI). Six patients bitten by Crotalus durissus terrificus snakes were treated at the Emergency Unit and Tropical Diseases Unit of Botucatu School of Medicine, UNESP, São Paulo State, Brazil. After receiving specific serotherapy, the patients were submitted to MR of the bite site. Post contrast T1 and T2 spin-echo MRI were obtained revealing the following lesions: edema associated with hemorrhage in subcutaneous and muscular tissue (n=3), edema in subcutaneous tissue (n=2), and perimuscular hemorrhage (n=1). In this study, MR demonstrated a local effect of Crotalus durissus terrificus...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Crotalus durissus terrificus; Muscular damage; Edema; Hemorrhage; Magnetic resonance.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302002000100005
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Surgical adhesives J. Venom. Anim. Toxins
THOMAZINI-SANTOS,I. A.; BARRAVIERA,S. R. C. S.; MENDES-GIANNINI,M. J. S.; BARRAVIERA,B..
The authors have performed a literature review of surgical adhesives, such as cyanoacrylate, collagen gelatin, and fibrin glue. They have included different types of commercial and non-commercial fibrin sealants and have reported on the different components in these adhesives, such as fibrinogen, cryoprecipitate, bovine thrombin, and thrombin-like fraction of snake venom.
Tipo: Info:eu-repo/semantics/review Palavras-chave: Fibrin glue; Surgical adhesives; Collagen gelatin; Cyanoacrylates; Fibrinogen; Cryoprecipitate; Bovine thrombin; Thrombin-like fraction; Snake venom.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302001000200002
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THE EVALUATION OF CLOTTING TIME IN BOVINE THROMBIN, REPTILASE ® , AND THROMBIN-LIKE FRACTION OF Crotalus durissus terrificus VENOM USING BOVINE, EQUINE, OVINE, BUBALINE AND HUMAN CRYOPRECIPITATES J. Venom. Anim. Toxins
THOMAZINI-SANTOS,I. A.; GIANNINI,M. J. S. M.; TOSCANO,E.; MACHADO,P.E.A.; LIMA,C. R. G.; BARRAVIERA,B..
The objective of this study was to evaluate the effects of the thrombin-like fraction of Crotalus durissus terrificus venom, Reptilase<img SRC="http:/img/fbpe/jvat/v4n2/image119.gif"> , and bovine thrombin of fibrinogen pools on bovine, equine, ovine, bubaline and human cryoprecipitates. The authors also made a comparative study between animal and human cryoprecipitates to see if any there was any possibility of future use in medicine. Fibrinogen levels in cryoprecipitate were studied using 48 blood samples obtained as follows:12 samples from humans, 9 from bovine, 10 from equine, 10 from ovine and 7 from bubaline. The results obtained showed average levels of 375.50 mg % for humans, 218.33 mg % for bovine, 240.80 mg % for equine, 267.70 mg % for...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Thrombin-like fraction bovine thrombin Reptilase<; Img SRC="http:/img/fbpe/jvat/v4n2/image119.gif">; Cryoprecipitate.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301998000200004
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THE EVOLUTION OF SCORPIONISM IN BRAZIL IN RECENT YEARS J. Venom. Anim. Toxins
LOURENÇO,W. R.; CLOUDSLEY-THOMPSON,J. L.; CUELLAR,O.; EICKSTEDT,V. R. D. VON; BARRAVIERA,B.; KNOX,M. B..
In this paper further information concerning the ecological and biogeographical aspects of scorpionism is presented. Some of the information already outlined in three previous publications(10,14,16) is assessed, and new data given concerning the pattern of distribution presented by Tityus serrulatus in Brazil. Some new ideas are also proposed regarding the possible evolutionary advantages and disadvantages of parthenogenesis versus sexuality in both the short-term and the long-term.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Scorpionism; Brazil; Tityus serrulatus.
Ano: 1996 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301996000200005
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TISSUE DAMAGE CAUSED BY Bothrops sp ENVENOMING EVALUATED BY MAGNETIC RESONANCE IMAGING (MRI) J. Venom. Anim. Toxins
FONSECA,M. G.; MATHIAS,M. R. C.; YAMASHITA,S.; MORCELI,J.; BARRAVIERA,B..
The objective of this clinical study was to evaluate local tissue damage caused by Bothrops sp envenoming in relation to lesion type and damaged tissues using magnetic resonance imaging (MRI). Fifteen patients bitten by Bothrops snakes were treated at the Emergency Unit of the Tropical Diseases Unit at the University Hospital, Botucatu School of Medicine, UNESP, São Paulo State, Brazil. After receiving specific serotherapy, the patients were submitted to MR of the bite site. T1 spin-echo MRI were obtained revealing the following lesions: edema (n=9), edema associated with hemorrhage (n=5), and hemorrhage (n=1). Perimuscular areas (n=6) and subcutaneous tissues (n=5) were the most affected, followed by muscular tissues (n=4). It is important to mention that...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bothrops sp; Magnetic resonance imaging; Tissue damage; Hemorrhage; Myonecrosis.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302002000100009
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Tissue necrosis after canine bothropic envenoming: a case report J. Venom. Anim. Toxins
FERREIRA JÚNIOR,R. S.; BARRAVIERA,B..
The authors report a case of bothropic envenoming in a male Cocker Spaniel. The animal was bitten in the ventral thoracic region, receiving treatment 4 hours later. Clinical examination revealed an extensive, painful and area of firm edema, absence of local or systemic hemorrhage, without evident neurological alterations. Clinical diagnosis was mild bothropic envenoming. Treatment consisted of 5 vials of polyvalent snake antivenom, two vials administered intravenously and three subcutaneously. Blood clotting time was always within normal values. Two days after envenoming, the animal showed hyperthermia and received enrofloxacin (5mg/kg/24h) for 10 days and ketoprofen (1mg/kg/24h) for 5 days. Seventy-two hours after envenoming, extensive subcutaneous,...
Tipo: Info:eu-repo/semantics/report Palavras-chave: Bothrops; Necrosis; Bothropic envenoming; Dog.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302001000200011
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USE OF AN ELISA ASSAY TO EVALUATE VENOM, ANTIVENOM, IgG AND IgM HUMAN ANTIBODY LEVELS IN SERUM AND CEREBROSPINAL FLUID FROM PATIENTS BITTEN BY Crotalus durissus terrificus IN BRAZIL J. Venom. Anim. Toxins
BARRAVIERA,B.; SARTORI,A.; PEREIRA DA SILVA,M. F.; KANENO,R.; PERAÇOLI,M. T. S..
A sandwich-type ELISA technique for specific and sensitive detection of Crotalus durissus terrificus venom antigens, horse-antivenom, human IgG and IgM antibodies was set up. Sixteen patients, 13 males and 3 females aged between 13 to 63 years (mean 33 ± 15) bitten by Crotalus durissus terrificus snakes were studied. Of the 15 patients, 6 had previously received anti-Crotalus venom and no seric venom was detected. For the other 9 patients studied, the venom levels ranged from 2 to 108 ng/ml according to the severity of each case. Seric antivenom was detected up to 44 days after the bite. IgM human antibody levels against Crotalus venom were higher between 3 and 18 days after specific treatment. IgG human antibody levels against Crotalus venom were detected...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Enzyme-linked immunosorbent assay; Crotalus durissus terrificus; Venom; Antivenom; Antibodies; Cerebrospinal fluid.
Ano: 1996 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301996000100003
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USE OF FIBRIN GLUE DERIVED FROM SNAKE VENOM IN TESTICULAR BIOPSY OF RAMS J. Venom. Anim. Toxins
SARTORI FILHO,R.; PRESTES,N. C.; THOMAZINI,I. A.; MENDES-GIANNINI,M. J.; TOSCANO,E.; CANAVESSI,A. M. O.; BARRAVIERA,B..
Sequelae due to testicular biopsy such as hemorrhage, adhesion and fibrosis may be limiting factors to the use of this surgical procedure. Fibrin glue (FG) derived from snake venom was used to minimize these sequelae, as well as to evaluate its healing property in tunica vaginalis and scrotal skin of rams. Applicability of fibrin glue derived from snake venom was tested in different tissues of other animals such as in sciatic nerve and colon of rats and skin of rabbits. In the present study, 30 healthy adult rams were used. They were divided into 3 groups of 10 animals each as follows: G1: fibrin glue group (application of fibrin glue on puncture sites and skin incisions after bilateral testicular biopsy with a Tru-Cut needle); G2: swab/nylon group...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Fibrin tecidual adhesive; Snake venoms; Biopsy; Testicle; Ovine.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301998000100003
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USE OF HONEY AS NUTRITIONAL AND THERAPEUTIC SUPPLEMENT IN THE TREATMENT OF INFECTIOUS DISEASES J. Venom. Anim. Toxins
PEREIRA,P.C.M.; BARRAVIERA,B.; BURINI,R.C.; SOARES,A.M.V.C.; BERTANI,M.A..
Honey, royal jelly, propolis, materials produced and/or gathered by Apis mellifera honeybees have been used as food and medication for centuries(6,7,8). Although extensively used, honeybee products have become a matter of interest and controversy for years. Honey, well known as healthy and natural food, has shown therapeutic properties in the treatment of digestive, respiratory, cardiac and rheumatic disorders, among others(4). Several studies have reported honey's immunological, antibacterial, antiinflammatory, antipyretic properties besides its importance in terms of energy intake(3,5). Furthermore, honey has proved to possesses wound healing and analgesic actions(1,2). Honey and propolis are also known to be effective in the treatment of respiratory...
Tipo: Info:eu-repo/semantics/report Palavras-chave: Honey; Nutritional supplement; Apis mellifera; Paracoccidioidomycosis; Tuberculosis.
Ano: 1995 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301995000200006
Registros recuperados: 16
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